Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Replenish BlendBifidobacterium lactis BL818, Lactobacillus acidophilus (SD-5221),Lactobacillus paracasei (SD-5218), Bifidobacterium lactis (SD-5220),Raw Whole Food Probiotic Blend: Bulgarian Yogurt (milk)Concentrate, ^Eastern European Wild Kefir Culture containingBifidobacterium lactis, Bifidobacterium longum, Lactobacillusacidophilus, Lactobacillus brevis, Lactobacillus bulgaricus,Lactobacillus casei, Lactobacillus fermentum, Lactobacillushelveticus, Lactobacillus kefiranofaciens, Lactobacillus kefirgranum,Lactobacillus rhamnosus, Lactococcus lactis, Lactococcus cremoris,Streptococcus thermophilus, Lactobacillus kefir, Lactobacillusparakefir, Lactobacillus plantarum, Lactococcus lactis biovardiacetylactis, Leuconostoc lactis, Leuconostoc mesenteroides,Leuconostoc cremoris, Leuconostoc dextranicum, Kluyveromycesmarxianus, Brettanomyces anomalus, Debaryomyces hansenii,Saccharomyces unisporus, Saccharomyces turicensis,Saccharomyces cerevisiae, Saccharomyces exiguus,Torulaspora delbrueckii
100 Billion CFU¹
+
Protein-Digesting Enzyme BlendProtease, Acid Protease, Protease S
50 mg
+
Eastern European Raw Fruit and Veggie BlendRed Bell Pepper (Fruit), Green Pea (Seed), Carrot (Root), Plum (Fruit), Cherry (Fruit), Strawberry (Fruit), Raspberry (Fruit)
45 mg
+
Top Medical Research Studies
9
We explored how Lactobacillus rhamnosus BFE5264 affects cholesterol levels using a mouse model on a high-cholesterol diet. This study revealed that this strain significantly reduced serum cholesterol levels while also altering the gut microbiome and increasing beneficial short-chain fatty acids. The findings suggest that L. rhamnosus could regulate cholesterol metabolism in the liver, showing effects similar to those of statin medications. These results highlight the potential of probiotics as a novel approach for managing cholesterol levels.
Read More
7
We investigated the impact of two probiotic strains, Lactobacillus rhamnosus BFE5264 and Lactiplantibacillus plantarum NR74, on high cholesterol levels in a murine model. The results indicated that these probiotics help reduce cholesterol absorption in the intestines and support liver metabolism.
Specifically, L. rhamnosus was particularly effective in boosting cholesterol processing in the liver. However, as this study focused on animal models, more research is needed to confirm these findings in humans.
Overall, these probiotics show promise for managing diet-related hypercholesterolemia.
Specifically, L. rhamnosus was particularly effective in boosting cholesterol processing in the liver. However, as this study focused on animal models, more research is needed to confirm these findings in humans.
Overall, these probiotics show promise for managing diet-related hypercholesterolemia.
Read More
9
Lactobacillus rhamnosus shows cholesterol-lowering effects
We examined the potential of Lactobacillus rhamnosus and other strains to lower cholesterol levels. Through in vitro testing, we observed impressive cholesterol reduction rates, achieving up to 91% decrease after 120 hours. When we moved to in vivo studies using rats fed fermented milk, we noted reductions in overall cholesterol, LDL, and triglycerides, while also enhancing HDL levels. Importantly, these probiotic strains demonstrated safety and effectiveness in their role as natural options for managing high cholesterol.
Read More
Most Useful Reviews
9
Improved health overall
5 people found this helpful
This product is a godsend! I used to have issues with constipation and yeast infections, but after my first bottle, it resolved both problems. I'm now on my third bottle and feeling fantastic. I maintain a healthy diet low in sugar and devoid of yeast, which significantly aids in managing the yeast infection. It's also beneficial for those with diabetes, as it helps introduce good bacteria into the gut while eliminating the bad, thereby lowering blood sugar over time. I swear by this product 100% and will continue daily use. I highly recommend it to everyone!
Read More
7.5
Reduced cholesterol effects
9 people found this helpful
Best probiotics! I’m a holistic therapist and specialise in colon hydrotherapy. When evaluating a patient, I review their medical history, particularly their antibiotic use. Observing their diet reveals why they suffer from gut issues. My primary recommendation is Ultimate Care, as leftovers from meat can decompose in the small intestine and colon, causing significant problems. I explain the necessity of Lactobacillus and Bifidobacterium, but I emphasise the benefits of yeasts, including their probiotic effects, biodegradation of phytate, folate biofortification, detoxification of mycotoxins, lowering serum cholesterol, and their antioxidative, antimutagenic, and antitumour properties.
Read More
8
Cholesterol reduction noted
1 people found this helpful
I firmly believe this is the best probiotic on the market. After researching, I chose this product as the company stands behind its quality. Living in Europe, the fact that this product doesn't need refrigeration during transport is crucial for the formula's stability. My gut feels significantly better. No more bloating or constipation after ten days of use. I highly recommend this probiotic for anyone who has taken antibiotics. I will repurchase this repeatedly.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8
- All Researches
9
We investigated the effects of Lactobacillus rhamnosus on high cholesterol and blood sugar levels in diabetic rats.
By using yogurt fermented with this probiotic, we noticed significant reductions in blood glucose and an increase in healthy cholesterol levels.
Within just four days of consuming the yogurt, notable changes in liver and kidney enzymes were observed, alongside improvements in lipid profiles.
While promising, further research is needed to confirm these benefits in humans.
By using yogurt fermented with this probiotic, we noticed significant reductions in blood glucose and an increase in healthy cholesterol levels.
Within just four days of consuming the yogurt, notable changes in liver and kidney enzymes were observed, alongside improvements in lipid profiles.
While promising, further research is needed to confirm these benefits in humans.
Read More
9
We investigated the cholesterol-lowering effects of two specific probiotic strains, FM9 and Y57, using a high-fat diet model in male Wistar rats. Over 30 days, these strains demonstrated a significant ability to improve blood lipid profiles.
Notably, FM9 and Y57 reduced serum cholesterol levels by 9% and 8%, respectively, while also improving "good" HDL cholesterol levels more than the statin treatment.
These results suggest that probiotics like FM9 and Y57 may offer a natural alternative to conventional medications for managing cholesterol, with the potential for anti-obesity benefits too, though clinical trials are needed to confirm these effects in humans.
Notably, FM9 and Y57 reduced serum cholesterol levels by 9% and 8%, respectively, while also improving "good" HDL cholesterol levels more than the statin treatment.
These results suggest that probiotics like FM9 and Y57 may offer a natural alternative to conventional medications for managing cholesterol, with the potential for anti-obesity benefits too, though clinical trials are needed to confirm these effects in humans.
Read More
9
We explored how two specific probiotic strains, Lactobacillus johnsonni 3121 and Lactobacillus rhamnosus 86, impact high cholesterol conditions linked to obesity. In our study using obese mice on a high-fat diet, we observed that daily doses of these probiotics over 12 weeks led to significant improvements in cholesterol levels.
Notably, both strains reduced lipid accumulation and influenced the genes involved in fat cell development. Additionally, they helped restore the balance of gut bacteria affected by obesity. These findings suggest that these probiotics could be valuable in managing high cholesterol and obesity-related health issues.
Notably, both strains reduced lipid accumulation and influenced the genes involved in fat cell development. Additionally, they helped restore the balance of gut bacteria affected by obesity. These findings suggest that these probiotics could be valuable in managing high cholesterol and obesity-related health issues.
Read More
9
Lactobacillus rhamnosus shows cholesterol-lowering effects
We examined the potential of Lactobacillus rhamnosus and other strains to lower cholesterol levels. Through in vitro testing, we observed impressive cholesterol reduction rates, achieving up to 91% decrease after 120 hours. When we moved to in vivo studies using rats fed fermented milk, we noted reductions in overall cholesterol, LDL, and triglycerides, while also enhancing HDL levels. Importantly, these probiotic strains demonstrated safety and effectiveness in their role as natural options for managing high cholesterol.
Read More
9
We explored how Lactobacillus rhamnosus BFE5264 affects cholesterol levels using a mouse model on a high-cholesterol diet. This study revealed that this strain significantly reduced serum cholesterol levels while also altering the gut microbiome and increasing beneficial short-chain fatty acids. The findings suggest that L. rhamnosus could regulate cholesterol metabolism in the liver, showing effects similar to those of statin medications. These results highlight the potential of probiotics as a novel approach for managing cholesterol levels.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved health overall
5 people found this helpful
This product is a godsend! I used to have issues with constipation and yeast infections, but after my first bottle, it resolved both problems. I'm now on my third bottle and feeling fantastic. I maintain a healthy diet low in sugar and devoid of yeast, which significantly aids in managing the yeast infection. It's also beneficial for those with diabetes, as it helps introduce good bacteria into the gut while eliminating the bad, thereby lowering blood sugar over time. I swear by this product 100% and will continue daily use. I highly recommend it to everyone!
Read More
7.5
Reduced cholesterol effects
9 people found this helpful
Best probiotics! I’m a holistic therapist and specialise in colon hydrotherapy. When evaluating a patient, I review their medical history, particularly their antibiotic use. Observing their diet reveals why they suffer from gut issues. My primary recommendation is Ultimate Care, as leftovers from meat can decompose in the small intestine and colon, causing significant problems. I explain the necessity of Lactobacillus and Bifidobacterium, but I emphasise the benefits of yeasts, including their probiotic effects, biodegradation of phytate, folate biofortification, detoxification of mycotoxins, lowering serum cholesterol, and their antioxidative, antimutagenic, and antitumour properties.
Read More
8
Cholesterol reduction noted
1 people found this helpful
I firmly believe this is the best probiotic on the market. After researching, I chose this product as the company stands behind its quality. Living in Europe, the fact that this product doesn't need refrigeration during transport is crucial for the formula's stability. My gut feels significantly better. No more bloating or constipation after ten days of use. I highly recommend this probiotic for anyone who has taken antibiotics. I will repurchase this repeatedly.
Read More
7.5
Enhanced bowel function
1 people found this helpful
The most powerful and high-quality probiotic on iHerb. It can be taken in courses or after antibiotics and perfectly enhances bowel function.
Read More
Frequently Asked Questions
9
Improved health overall
5 people found this helpful
This product is a godsend! I used to have issues with constipation and yeast infections, but after my first bottle, it resolved both problems. I'm now on my third bottle and feeling fantastic. I maintain a healthy diet low in sugar and devoid of yeast, which significantly aids in managing the yeast infection. It's also beneficial for those with diabetes, as it helps introduce good bacteria into the gut while eliminating the bad, thereby lowering blood sugar over time. I swear by this product 100% and will continue daily use. I highly recommend it to everyone!
7.5
Reduced cholesterol effects
9 people found this helpful
Best probiotics! I’m a holistic therapist and specialise in colon hydrotherapy. When evaluating a patient, I review their medical history, particularly their antibiotic use. Observing their diet reveals why they suffer from gut issues. My primary recommendation is Ultimate Care, as leftovers from meat can decompose in the small intestine and colon, causing significant problems. I explain the necessity of Lactobacillus and Bifidobacterium, but I emphasise the benefits of yeasts, including their probiotic effects, biodegradation of phytate, folate biofortification, detoxification of mycotoxins, lowering serum cholesterol, and their antioxidative, antimutagenic, and antitumour properties.
8
Cholesterol reduction noted
1 people found this helpful
I firmly believe this is the best probiotic on the market. After researching, I chose this product as the company stands behind its quality. Living in Europe, the fact that this product doesn't need refrigeration during transport is crucial for the formula's stability. My gut feels significantly better. No more bloating or constipation after ten days of use. I highly recommend this probiotic for anyone who has taken antibiotics. I will repurchase this repeatedly.
7.5
Enhanced bowel function
1 people found this helpful
The most powerful and high-quality probiotic on iHerb. It can be taken in courses or after antibiotics and perfectly enhances bowel function.
9
Lactobacillus rhamnosus shows cholesterol-lowering effects
We examined the potential of Lactobacillus rhamnosus and other strains to lower cholesterol levels. Through in vitro testing, we observed impressive cholesterol reduction rates, achieving up to 91% decrease after 120 hours. When we moved to in vivo studies using rats fed fermented milk, we noted reductions in overall cholesterol, LDL, and triglycerides, while also enhancing HDL levels. Importantly, these probiotic strains demonstrated safety and effectiveness in their role as natural options for managing high cholesterol.
7
We explored how a new combination of Lactobacillus rhamnosus and xylo-oligosaccharides could help lower cholesterol levels. The study tested this synbiotic approach by simulating cholesterol-lowering effects in a lab setting.
Results suggested that it may work by down-regulating certain genes involved in cholesterol absorption and promoting a healthier gut microbiome. While promising, further research is needed to confirm its effectiveness in real-world conditions among people.
Results suggested that it may work by down-regulating certain genes involved in cholesterol absorption and promoting a healthier gut microbiome. While promising, further research is needed to confirm its effectiveness in real-world conditions among people.
9
We investigated the cholesterol-lowering effects of two specific probiotic strains, FM9 and Y57, using a high-fat diet model in male Wistar rats. Over 30 days, these strains demonstrated a significant ability to improve blood lipid profiles.
Notably, FM9 and Y57 reduced serum cholesterol levels by 9% and 8%, respectively, while also improving "good" HDL cholesterol levels more than the statin treatment.
These results suggest that probiotics like FM9 and Y57 may offer a natural alternative to conventional medications for managing cholesterol, with the potential for anti-obesity benefits too, though clinical trials are needed to confirm these effects in humans.
Notably, FM9 and Y57 reduced serum cholesterol levels by 9% and 8%, respectively, while also improving "good" HDL cholesterol levels more than the statin treatment.
These results suggest that probiotics like FM9 and Y57 may offer a natural alternative to conventional medications for managing cholesterol, with the potential for anti-obesity benefits too, though clinical trials are needed to confirm these effects in humans.
8
Probiotics lower cholesterol levels
We explored how an 8-week treatment with probiotics affects cholesterol and other health markers in women with high blood pressure. In a randomized, triple-blind study, participants took either a probiotic mix or a placebo.
The results were promising—those taking probiotics saw significant reductions in cholesterol levels and fasting glucose, and an increase in HDL-cholesterol. Although there was a slight drop in blood pressure, it wasn't statistically significant. Overall, we found that probiotics can positively influence cholesterol and some aspects of heart health in hypertensive women.
The results were promising—those taking probiotics saw significant reductions in cholesterol levels and fasting glucose, and an increase in HDL-cholesterol. Although there was a slight drop in blood pressure, it wasn't statistically significant. Overall, we found that probiotics can positively influence cholesterol and some aspects of heart health in hypertensive women.
References
- Correia Gomes D, Meza Alvarado JE, Zamora Briseño JA, Cano Sarmiento C, Camacho Morales A, et al. Maternal Supplementation with GG Improves Glucose Tolerance and Modulates the Intestinal Microbiota of Offspring. Diseases. 2024;12. doi:10.3390/diseases12120312
- Dang L, Li D, Mu Q, Zhang N, Li C, et al. Youth-derived Lactobacillus rhamnosus with prebiotic xylo-oligosaccharide exhibits anti-hyperlipidemic effects as a novel synbiotic. Food Res Int. 2024;195:114976. doi:10.1016/j.foodres.2024.114976
- Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. doi:10.3390/nu16091331
- Negm El-Dein A, Ezzat A, Aly HF, Awad G, Farid M. Lactobacillus-fermented yogurt exerts hypoglycemic, hypocholesterolemic, and anti-inflammatory activities in STZ-induced diabetic Wistar rats. Nutr Res. 2022;108:22. doi:10.1016/j.nutres.2022.10.003
- Zafar H, Ain NU, Alshammari A, Alghamdi S, Raja H, et al. FM9 and Y57 Are as Effective as Statins at Improving Blood Lipid Profile in High Cholesterol, High-Fat Diet Model in Male Wistar Rats. Nutrients. 2022;14. doi:10.3390/nu14081654
- Yoon H, Lee Y, Kang HJ, Ju J, Ji Y, et al. Two putative probiotic strains improve diet-induced hypercholesterolemia through modulating intestinal cholesterol uptake and hepatic cholesterol efflux. J Appl Microbiol. 2022;132:562. doi:10.1111/jam.15181
- Daliri EB, Kim Y, Do Y, Chelliah R, Oh DH. In Vitro and In Vivo Cholesterol Reducing Ability and Safety of Probiotic Candidates Isolated from Korean Fermented Soya Beans. Probiotics Antimicrob Proteins. 2022;14:87. doi:10.1007/s12602-021-09798-0
- Lee CS, Park MH, Kim BK, Kim SH. Antiobesity Effect of Novel Probiotic Strains in a Mouse Model of High-Fat Diet-Induced Obesity. Probiotics Antimicrob Proteins. 2021;13:1054. doi:10.1007/s12602-021-09752-0
- El-Dein AN, Nour El-Deen AM, El-Shatoury EH, Awad GA, Ibrahim MK, et al. Assessment of exopolysaccharides, bacteriocins and in vitro and in vivo hypocholesterolemic potential of some Egyptian Lactobacillus spp. Int J Biol Macromol. 2021;173:66. doi:10.1016/j.ijbiomac.2021.01.107
- Das S, Mishra BK, Hati S. Techno-functional characterization of indigenous isolates from the traditional fermented foods of Meghalaya, India. Curr Res Food Sci. 2020;3:9. doi:10.1016/j.crfs.2020.01.002
- Romão da Silva LF, de Oliveira Y, de Souza EL, de Luna Freire MO, Braga VA, et al. Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial. Food Funct. 2020;11:7152. doi:10.1039/d0fo01661f
- Wa Y, Yin B, He Y, Xi W, Huang Y, et al. Effects of Single Probiotic- and Combined Probiotic-Fermented Milk on Lipid Metabolism in Hyperlipidemic Rats. Front Microbiol. 2019;10:1312. doi:10.3389/fmicb.2019.01312
- Yan Y, Zhang F, Chai Z, Liu M, Battino M, et al. Mixed fermentation of blueberry pomace with L. rhamnosus GG and L. plantarum-1: Enhance the active ingredient, antioxidant activity and health-promoting benefits. Food Chem Toxicol. 2019;131:110541. doi:10.1016/j.fct.2019.05.049
- Park S, Kang J, Choi S, Park H, Hwang E, et al. Cholesterol-lowering effect of Lactobacillus rhamnosus BFE5264 and its influence on the gut microbiome and propionate level in a murine model. PLoS One. 2018;13:e0203150. doi:10.1371/journal.pone.0203150
- Oh NS, Joung JY, Lee JY, Kim Y. Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces. PLoS One. 2018;13:e0192021. doi:10.1371/journal.pone.0192021
- Roselli M, Devirgiliis C, Zinno P, Guantario B, Finamore A, et al. Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition. Genes Nutr. 2017;12:25. doi:10.1186/s12263-017-0583-1
- Barache N, Belguesmia Y, Zeghbib W, Ladjouzi R, Ouarabi L, et al. Characterization and Biological In Vitro Screening of Probiotic Yeast Strains Isolated from Algerian Fruits. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10389-y
- Selim S, Abdel-Megeid NS, Alhotan RA, Ebrahim A, Hussein E. Nutraceuticals vs. antibiotic growth promoters: differential impacts on performance, meat quality, blood lipids, cecal microbiota, and organ histomorphology of broiler chicken. Poult Sci. 2024;103:103971. doi:10.1016/j.psj.2024.103971
- Hosseini H, Abbasi A, Sabahi S, Akrami S, Yousefi-Avarvand A. Assessing the Potential Biological Activities of Postbiotics Derived from Saccharomyces cerevisiae: An In Vitro Study. Probiotics Antimicrob Proteins. 2024;16:1348. doi:10.1007/s12602-023-10117-y
- Wang Y, Han C, Cheng J, Wang Z, Liu L, et al. Fermented Cerasus humilis fruits protect against high-fat diet induced hyperlipidemia which is associated with alteration of gut microbiota. J Sci Food Agric. 2023;103:2554. doi:10.1002/jsfa.12377
- Razavi SA, Pourjafar M, Hajimohammadi A, Valizadeh R, Naserian AA, et al. Effects of dietary supplementation of bentonite and Saccharomyces cerevisiae cell wall on acute-phase protein and liver function in high-producing dairy cows during transition period. Trop Anim Health Prod. 2019;51:1225. doi:10.1007/s11250-019-01815-3
